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alternative protocols (e.g., 100 mcg every other day) may be selected based on clinical response and laboratory indices

The advanced protocol should only be implemented after successful tolerance of lower doses and under appropriate medical supervision

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)

When AOD 9604 binds to beta-3 adrenergic receptors on white fat cells, it triggers a cascade that starts with adenylyl cyclase activation